|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
While LGP2 functions to modulate inflammatory signaling, RIG-I and MDA5 together are essential for M1 macrophage polarization in vivo and the control of WNV infection through potential downstream control of ATF4 and SMAD4 to regulate target gene expression for cell polarization.
|
31409781 |
2019 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Using LGP2(+/+) and LGP2(-/-) mouse cells, we show that endogenous LGP2 decreased IFN production during H3N2 virus infection 3- to 4-fold.
|
22837208 |
2012 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
TRIM31 was recruited to mitochondria after viral infection and specifically regulated antiviral signaling mediated by RLR pattern-recognition receptors.
|
27992402 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Together, our findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2, which opens the door to novel therapeutic strategies in interferon-related autoimmune diseases and cancer.
|
29032202 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Together, our findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2, which opens the door to novel therapeutic strategies in interferon-related autoimmune diseases and cancer.
|
29032202 |
2017 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Together, our findings indicate a possible role of PACT in regulating the Cardiovirus-triggered immune responses mediated by MDA5 and LGP2, which opens the door to novel therapeutic strategies in interferon-related autoimmune diseases and cancer.
|
29032202 |
2017 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate the collective contribution of PRRs and IL-1R signalling to RSV immunity, we generated Myd88/Trif/Mavs(-/-) mice that are deficient in signalling by all TLRs, RLRs and IL-1R, as well as other cytokine receptors such as IL-18 receptor.
|
26688048 |
2015 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of LGP2 in virus infection is controversial, and the only LGP2 experiments previously carried out with mammalian influenza A viruses employed an attenuated, mouse-adapted H1N1 A/PR/8/34 (PR8) virus that does not encode the NS1 protein.
|
22837208 |
2012 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA.
|
24743923 |
2014 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I, melanoma-differentiation-associated gene 5 (MDA5), and LGP2, function as cytoplasmic virus sensor proteins during viral infection.
|
29939295 |
2018 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Results indicate that LGP2 can inhibit antiviral signaling independently of dsRNA or virus infection intermediates by engaging in a protein complex with IPS-1.
|
17020950 |
2006 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
Q-MSI revealed previously unknown RNA mitochondrial receptor orientations, and the interaction between the viral RNA receptor called LGP2 with the RNA helicase encoded by the hepatitis virus.
|
30471070 |
2019 |
|
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Q-MSI revealed previously unknown RNA mitochondrial receptor orientations, and the interaction between the viral RNA receptor called LGP2 with the RNA helicase encoded by the hepatitis virus.
|
30471070 |
2019 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Q-MSI confirmed previously reported RLR interactions and revealed an interaction between HCV helicase and LGP2.
|
28483922 |
2017 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Positive cytoplasmic LGP2 expression in tumor tissues could predict a favorable outcome in NB patients independent of other prognostic factors.
|
30179292 |
2018 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Polyinosine-polycytidylic acid [pIC] is a synthetic dsRNA that acts as an immune agonist of TLR3 and RLR to activate dendritic and natural killer cells that can kill tumor cells. pIC can also trigger apoptosis in pancreatic ductal adenocarcinoma cells (PDAC) but its mechanism of action is obscure.
|
25205107 |
2014 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PBRM1 was found to be downregulated in primary tissues from patients with CRC or IBD, and its expression correlated negatively with that of RLR genes and interferon-stimulated genes in CRC samples.
|
28940253 |
2018 |
|
Cardiovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.
|
29032202 |
2017 |
|
Duck viral enteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, these findings indicated that MDA5 restricted DEV replication and LGP2 plays a critical role in MDA5-mediated antiviral activity against DEV.
|
31675523 |
2019 |
|
Virus Diseases
|
0.080 |
Biomarker
|
group |
BEFREE |
Our findings not only reveal a role of mitochondria in RLR mediated antiviral signaling but also suggest that mitochondria contribute to the regulation of persistent viral infection.
|
23830853 |
2013 |
|
Aeromonas hydrophila infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, RLR family consist of three conserved members (RIG-I, MDA5 and LGP2) as well as two adaptors (IPS-1 and STING) in C. idella. mRNA expression analyses of TLRs, RLRs and their adaptors indicated that most members are sustainably expressed in multiple tissues before and after grass carp reovirus (GCRV) or Aeromonas hydrophila infection, while TLR9, TLR20a/b, TLR25, TIRAP, SARM1 and STING are transiently expressed in specific tissues.
|
28559111 |
2017 |
|
Hepatitis C
|
0.020 |
Biomarker
|
disease |
BEFREE |
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
|
28090671 |
2017 |
|
Influenza A virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is intriguing that LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response.
|
22837208 |
2012 |
|
Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.
|
29032202 |
2017 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.
|
30179292 |
2018 |